Tuesday, 7 November 2017

Warfarin prevents cancer - A new discovery or a scientific myth?

Recently an article published in JAMA pointed out towards possible benefits of warfarin in terms of preventing any type of cancer. (1) The study employed the Norwegian registry with over a million patients involved in the study. The authors concluded that warfarin decreases the incidence of cancer, with incidence risk ratio of 0.84, 95% CI 0.82-0.86. As good as the results and sample size sounds, the study itself was plagued by some serious limitations.

Monday, 6 November 2017

Preventing Recurrence of stroke in cryptogenic Stroke patients with PFO closure

Cryptogenic stroke is defined as stroke in which cause is indeterminate or stroke without underlying embolic, ischemic or hypertensive etiology. (1) When a patient comes in with cryptogenic stroke, the treatment is usually similar to stroke with any known cause such as thrombolytics and antiplatelets. For secondary prevention, recommended guidelines include using a single antiplatelet agent such as aspirin or clopidogrel lifelong or combination of any of these with dipyridamole.(2)